KDM3B as a Genotype-Specific Target in IDH1/2-Mutant Clonal Hematopoiesis and Leukemia

Dr. Fay will study the histone demethylase KDM3B, a genotype-specific functional dependency in premalignant IDH1/2-mutant clonal hematopoiesis (CH), which confers an increased risk of acute myeloid leukemia (AML). She aims to understand how KDM3B drives clonal expansion and progression to malignancy and to demonstrate that targeting KDM3B can prevent or regress IDH1/2-mutant AML.