Targeting Cellular States and Plasticity in Glioblastoma


2020 Emerging Leader Award

Dr. Suvà is working to better understand and treat the aggressive brain cancer glioblastoma multiforme (GBM). Researchers in his laboratory have recently found that GBM cells can exist in one of four biochemically distinct cellular states and that the ratio of cells in these states can vary in tumors. They are now working to characterize the genetics and tumor microenvironments that lead to each state, determine the relationship and transitions between them, and identify drugs that can best target each one. Dr. Suvà is an Assistant Professor in the Department of Pathology at Massachusetts General Hospital and an Institute Member at the Broad Institute of MIT and Harvard. His expertise is in neuro-oncology and in single-cell genomic technologies. He obtained his MD and PhD in Lausanne, Switzerland.

PUBLISHED RESEARCH

Suvà ML, Tirosh I. The Glioma Stem Cell Model in the Era of Single-Cell Genomics. Cancer Cell. 2020.

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