Gregory L. Beatty, MD, PhD, University of Pennsylvania, will study how the liver affects cancer immunotherapy efficacy. The goals of his project are to define determinants of the liver response to human cancer and to interrogate mechanisms by which the liver coordinates immune dysfunction. In doing so, Beatty aims to identify novel therapeutic targets and new treatments for patients with cancer.
“I am so thrilled to receive this AACR-The Mark Foundation for Cancer Research “Science of the Patient” Grant, which will allow my research team and me to conduct studies on the connection between the liver, cancer, and immunity, and follow our vision of broadening the efficacy of immunotherapy,” said Beatty.
Content courtesy of AACR
PUBLISHED RESEARCH
Beatty GL, Delman D, Yu J, Liu M, Li JH, Zhang L, Lee JW, Chang RB, Bahary N, Kennedy EP, Wang-Gillam A, Rossi GR, Garrido-Laguna I. Treatment Response in First-Line Metastatic Pancreatic Ductal Adenocarcinoma Is Stratified By a Composite Index of Tumor Proliferation and CD8 T-Cell Infiltration. Clin Cancer Res. 2023.
Plesset J, Stone ML, McVey JC, Coho H, Markowitz K, Coho K, Lee J, Thickens AS, Delman D, Beatty GL. TLR2 signaling regulates T cell exclusion in pancreatic ductal adenocarcinoma. JCI Insight. 2026.
Stone ML, Lee J, Lee JW, Coho H, Tariveranmoshabad M, Wattenberg MM, Choi H, Herrera VM, Xue Y, Choi-Bose S, Zingone SK, Patel D, Markowitz K, Delman D, Balachandran VP, Beatty GL. Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins. Nat Immunol. 2024.
Li Y, Chang RB, Stone ML, Delman D, Markowitz K, Xue Y, Coho H, Herrera VM, Li JH, Zhang L, Choi-Bose S, Giannone M, Shin SM, Coyne EM, Hernandez A, Gross NE, Charmsaz S, Ho WJ, Lee JW, Beatty GL. Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer. Cell Rep Med. 2024.
Lee J, Beatty GL. Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer. Cancers (Basel). 2021.