Decoding Delta One T Cell Adaptation and Regulation in Colorectal Cancer for Improved Immunotherapy

Dr. Blanco Domínguez’s research has focused on understanding γδ T cells within the solid tumor microenvironment and harnessing their therapeutic potential for cancer immunotherapy. He played a central role in the development of Delta One T cells, a Vδ1-enriched γδ T cell–based therapy currently under clinical evaluation, demonstrating their preclinical efficacy in colorectal cancer as a proof of concept for solid tumors. As an EACR–Mark Foundation Fellow at GIMM, he is leading research programs aimed at optimizing γδ T cell–based therapies for colorectal cancer and accelerating their path toward clinical application.