E. John Wherry, PhD

Dr. Wherry is the Richard and Barbara Schiffrin President’s Distinguished Professor of Microbiology, and Director of the Institute for Immunology at the University of Pennsylvania. Dr. Wherry’s expertise focuses on T cell exhaustion in chronic infections and cancer. Dr. Wherry has made substantial contributions to our understanding of the molecular mechanisms of T cell exhaustion, including defining the roles of inhibitory receptors and delineating the central transcriptional and epigenetic pathways in the biology of exhausted T cells. His group’s efforts are focused on understanding the mechanisms of “checkpoint” pathways such as PD-1, through the use of tools such as transcriptional profiling, genomics, computational biology, and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion and other forms of T cell and immune perturbation in preclinical and clinical settings.