Jeroen Roose, PhD

Dr. Jeroen Roose is a tenured Principal Investigator and Vice Chair of Anatomy at the University of California, San Francisco. He is also a co-founder of UCSF’s ImmunoX. During his PhD, he trained with Professor Hans Clevers and investigated Wnt signaling in cancer. His postdoctoral training with Professor Arthur Weiss focused on Ras signaling in T lymphocytes. The Roose lab studies the impact Ras-kinase signals have on cell fate decisions in health and disease. The Roose lab team explores three cell fates and disease types: T cells causing autoimmunity, bone marrow progenitors in leukemias, and epithelial stem and progenitor cells in carcinomas. By taking a collaborative approach working with biophysicists, computational engineers, geneticists, and many clinicians, the Roose research team spans the gamut from fundamental science to pre-clinical trials. Dr. Roose also runs an organoid disease to biology team in UCSF’s Central Research Labs. He is a recipient of multiple grants and awards including support from the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and the National Heart, Lung, and Blood Institute. Dr. Roose received UCSF’s 2013 Postdoctoral Fellow Mentor Award. He is the director of the Graduate School Cell Biology course and Medical School Histology course. Dr. Roose serves as an ad hoc reviewer for multiple journals including Science, Nature, Immunity, Science Signaling, and EMBO and is a long-standing reviewer for the American Cancer Society. Dr. Roose is also a co-founder of Seal Biosciences, Inc.