Exploiting Lymphatic Transport for Early Detection

2020 Emerging Leader Award

Amanda Lund, PhD, New York University

Amanda Lund, PhD

Dr. Lund is developing a novel method for the early detection of tumor progression by focusing on biomarkers that are trafficked through the lymphatic system. Researchers in her laboratory are working to confirm that lymphatic vessels filter proteins secreted by tumors and that those secreted proteins are a rich source of cancer biomarkers. This research, initially focused on melanoma, will also determine whether proteins secreted into the lymph play a role in the early stages of tumor spreading and immune suppression. Dr. Lund earned a PhD from Rensselaer Polytechnic Institute and completed postdoctoral training at the Swiss Federal Institute of Technology Lausanne. Dr. Lund is an Associate Professor in the Ronald O. Perelman Department of Dermatology at NYU Langone Health.

published research

Steele MM, Lund AW. Afferent Lymphatic Transport and Peripheral Tissue Immunity. J Immunol. 2021.

Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. Melanoma models for the next generation of therapies. Cancer Cell. 2021.

Du Bois H, Heim TA, Lund AW. Tumor-draining lymph nodes: At the crossroads of metastasis and immunity. Sci Immunol. 2021.

Churchill MJ, du Bois H, Heim TA, Mudianto T, Steele MM, Nolz JC, Lund AW. Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin. J Exp Med. 2022.

Delclaux I, Ventre KS, Jones D, Lund AW. The tumor-draining lymph node as a reservoir for systemic immune surveillance. Trends Cancer. 2023.

Femel J, Hill C, Illa Bochaca I, Booth JL, Asnaashari TG, Steele MM, Moshiri AS, Do H, Zhong J, Osman I, Leachman SA, Tsujikawa T, White KP, Chang YH, Lund AW. Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma. Front Immunol. 2024.