Dr. Strom will use novel techniques to investigate whether the stiffness of the nucleus impacts the cancer cell’s ability to migrate through blood vessels and therefore its potential to metastasize.
PUBLISHED RESEARCH
Strom AR, Kim Y, Zhao H, Chang YC, Orlovsky ND, Košmrlj A, Storm C, Brangwynne CP. Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity. Cell. 2024.
Strom AR, Eeftens JM, Polyachenko Y, Weaver CJ, Watanabe HF, Bracha D, Orlovsky ND, Jumper CC, Jacobs WM, Brangwynne CP. Interplay of condensation and chromatin binding underlies BRD4 targeting. Mol Biol Cell. 2024.
Patil A, Strom AR, Paulo JA, Collings CK, Ruff KM, Shinn MK, Sankar A, Cervantes KS, Wauer T, St Laurent JD, Xu G, Becker LA, Gygi SP, Pappu RV, Brangwynne CP, Kadoch C. A disordered region controls cBAF activity via condensation and partner recruitment. Cell. 2023.
Lee DSW, Strom AR, Brangwynne CP. The mechanobiology of nuclear phase separation. APL Bioeng. 2022.
Jack A, Kim Y, Strom AR, Lee DSW, Williams B, Schaub JM, Kellogg EH, Finkelstein IJ, Ferro LS, Yildiz A, Brangwynne CP. Compartmentalization of telomeres through DNA-scaffolded phase separation. Dev Cell. 2022.
Strom AR, Biggs RJ, Banigan EJ, Wang X, Chiu K, Herman C, Collado J, Yue F, Ritland Politz JC, Tait LJ, Scalzo D, Telling A, Groudine M, Brangwynne CP, Marko JF, Stephens AD. HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics. Elife. 2021.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP. Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. Cell. 2020.
Strom AR, Brangwynne CP. The liquid nucleome – phase transitions in the nucleus at a glance. J Cell Sci. 2019.