Dr. Strom will use novel techniques to investigate whether the stiffness of the nucleus impacts the cancer cell’s ability to migrate through blood vessels and therefore its potential to metastasize.
Strom AR, Brangwynne CP. The liquid nucleome – phase transitions in the nucleus at a glance. J Cell Sci. 2019.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, Bracha D, Eeftens JM, Iwanicki A, Wang A, Wei MT, Whitney G, Lyons SM, Anderson P, Jacobs WM, Ivanov P, Brangwynne CP. Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. Cell. 2020.
Strom AR, Biggs RJ, Banigan EJ, Wang X, Chiu K, Herman C, Collado J, Yue F, Ritland Politz JC, Tait LJ, Scalzo D, Telling A, Groudine M, Brangwynne CP, Marko JF, Stephens AD. HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics. Elife. 2021.
Jack A, Kim Y, Strom AR, Lee DSW, Williams B, Schaub JM, Kellogg EH, Finkelstein IJ, Ferro LS, Yildiz A, Brangwynne CP. Compartmentalization of telomeres through DNA-scaffolded phase separation. Dev Cell. 2022.
Lee DSW, Strom AR, Brangwynne CP. The mechanobiology of nuclear phase separation. APL Bioeng. 2022.
Patil A, Strom AR, Paulo JA, Collings CK, Ruff KM, Shinn MK, Sankar A, Cervantes KS, Wauer T, St Laurent JD, Xu G, Becker LA, Gygi SP, Pappu RV, Brangwynne CP, Kadoch C. A disordered region controls cBAF activity via condensation and partner recruitment. Cell. 2023.