Origins and Therapeutic Vulnerabilities of Sex Bias in Cancer

2019 Emerging Leader Award

Andrew A. Lane, MD, PhD, Dana-Farber Cancer Institute

Andrew A. Lane, MD, PhD

Dr. Lane is studying the mechanisms underlying the marked differences in cancer biology between men and women, including significantly increased risk for nearly every tumor type in males as well as gender-specific differences in response to targeted and conventional therapy. Dr. Lane and his team will explore cancer sex differences by harnessing innovative technologies such as single-cell RNA sequencing, sex chromosome-specific analysis methods for cancer genomic data, and novel isogenic models of sex bias in malignancy. A physician-scientist, Dr. Lane is in the Department of Medical Oncology at the Dana-Farber Cancer Institute and Assistant Professor of Medicine at Harvard Medical School. He was awarded MD and PhD degrees from Washington University and completed a residency in internal medicine at Brigham and Women’s Hospital as well as a fellowship in hematology/oncology at the Dana-Farber Cancer Institute.


Togami K, Chung SS, Madan V, Booth CAG, Kenyon CM, Cabal-Hierro L, Taylor J, Kim SS, Griffin GK, Ghandi M, Li J, Li YY, Angelot-Delettre F, Biichle S, Seiler M, Buonamici S, Lovitch SB, Louissaint Jr. A, Morgan EA, Jardin F, Piccaluga PP, Weinstock DM, Hammerman PS, Yang H, Konopleva M, Pemmaraju N, Garnache-Ottou F, Abdel-Wahab O, Koeffler HP, Lane AA. Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis. Cancer Discov. 2021.

DePasquale EAK, Ssozi D, Ainciburu M, Good J, Noel J, Villanueva MA, Couturier CP, Shalek AK, Aranki SF, Mallidi HR, Griffin GK, Lane AA, van Galen P. Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm. Front Immunol. 2022.

Rheinbay E, Qi M, Bouyssou J, Oler AJ, Thumm L, Makiya M, Maric I, Klion AD, Lane AA. Genomics of PDGFR-rearranged hypereosinophilic syndrome. Blood Adv. 2023.

Griffin GK, Booth CAG, Togami K, Chung SS, Ssozi D, Verga JA, Bouyssou JM, Lee YS, Shanmugam V, Hornick JL, LeBoeuf NR, Morgan EA, Bernstein BE, Hovestadt V, van Galen P, Lane AA. Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin. Nature. 2023.

Qi M, Pang J, Mitsiades I, Lane AA, Rheinbay E. Loss of chromosome Y in primary tumors. Cell. 2023.

Lane AA, Garcia JS, Raulston EG, Garzon JLN, Galinsky I, Baxter EW, Leonard R, DeAngelo DJ, Luskin MR, Reilly CR, Stahl M, Stone RM, Vedula RS, Wadleigh M, Winer ES, Mughal TI, Brooks C, Gupta IV, Stevenson KE, Neuberg DS, Ren S, Keating JH, Konopleva MY, Stein AS, Pemmaraju N. Phase 1b trial of tagraxofusp in combination with azacitidine with or without venetoclax in acute myeloid leukemia. Blood Adv. 2023.

Luo Q, Raulston EG, Prado MA, Wu X, Gritsman K, Whalen KS, Yan K, Booth CAG, Xu R, van Galen P, Doench JG, Shimony S, Long HW, Neuberg DS, Paulo JA, Lane AA. Targetable leukaemia dependency on noncanonical PI3Kγ signalling. Nature. 2024.