Biological Mechanism and Risk Factor of Head and Neck Cancer in Blacks


In Partnership with The American Association for Cancer Research (2020-Present)

Fatemeh Momen-Heravi, PhD, Columbia University

Fatemeh Momen-Heravi, PhD

Fatemeh Momen-Heravi, PhD, Herbert Irving Comprehensive Cancer Center at Columbia University, aims to characterize the molecular features of head and neck squamous cell carcinoma (HNSCC) and identify transcriptomic changes associated with HNSCC in patients with African ancestry. Pathway analysis and integration of omics data will be used to uncover tumor vulnerabilities in Black patients for therapeutic intervention with the ultimate goal of developing personalized therapies and reducing health disparities.

This grant supports the important mission of reducing health disparities in head and neck cancer,” said Momen-Heravi. “Our research will transform the lives of many minority patients by understanding their specific risk factors and developing new personalized treatment.”

Content courtesy of AACR.

PUBLISHED RESEARCH

Wu X, Cheng YL, Matthen M, Yoon A, Schwartz GK, Bala S, Taylor AM, Momen-Heravi F. Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion. J Exp Clin Cancer Res. 2021.

Li J, Momen-Heravi F, Wu X, He K. Mechanism of METTL14 and m6A modification of lncRNA MALAT1 in the proliferation of oral squamous cell carcinoma cells. Oral Dis. 2022.

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