Characterize the Role of Non-Vesicular Cholesterol Transport in CD8+ T Cell Function

Damon Runyon - Mark Foundation Postdoctoral Fellow (2021-Present)

Yajing Gao, PhD, University of California, Los Angeles

Yajing Gao, PhD

Dr. Gao studies how the tumor microenvironment influences anti-tumor immune responses. Her research focuses on lipid metabolism in cytotoxic T lymphocytes (CTLs), a specialized population of white blood cells that kill malignant cells. To defend against this attack, tumors release lipid metabolites that can incapacitate infiltrating CTLs. Consequently, these metabolites create an immunosuppressive environment and promote tumor progression. Dr. Gao aims to unravel the pathways utilized by these harmful lipids. She is also investigating whether modifying lipid metabolism in immune cells can unleash CTL response and accelerate tumor shrinking. These studies have the potential to identify new therapeutic targets that will improve immunotherapy.

Content courtesy of Damon Runyon Cancer Research Foundation

published research

Xiao X, Kennelly JP, Feng AC, Cheng L, Romartinez-Alonso B, Bedard A, Gao Y, Cui L, Young SG, Schwabe JW, Tontonoz P. Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity. J Clin Invest. 2024.