Dr. Birsoy is using novel genetic tools to decipher the ways that tumor cells can overcome the toxic effects of reactive oxygen species (ROS) in different subcellular organelles. A better understanding of how the balance of reduction–oxidation is maintained in different cellular compartments could contribute to the development of cancer therapies that target ROS detoxification pathways. Dr. Birsoy aims to understand the role of oxidative metabolism in the initiation and progression of Ras-driven lung tumors, as well as to determine how mitochondrial glutathione modulates the immune response during tumor formation and in response to immunotherapy.
Dr. Birsoy received his undergraduate degree from Bilkent University in Turkey and a PhD from Rockefeller University. He completed a postdoctoral fellowship at the Whitehead Institute of the Massachusetts Institute of Technology. Dr. Birsoy’s lab studies how metabolic pathways regulate biological processes and contribute to various diseases including cancer.