Development and Application of a Pan-Cancer Diagnostic Test for Early Detection of Cancer


Momentum Fellow (2020-2021)

Dimitrios Mathios, MD, Johns Hopkins University School of Medicine

Dr. Mathios is developing and validating a liquid biopsy approach that detects early genetic and epigenetic features of cancer and could reduce unnecessary high-risk invasive procedures.

PUBLISHED RESEARCH

Mathios D, Johansen JS, Cristiano S, Medina JE, Phallen J, Larsen KR, Bruhm DC, Niknafs N, Ferreira L, Adleff V, Chiao JY, Leal A, Noe M, White JR, Arun AS, Hruban C, Annapragada AV, Jensen SØ, Ørntoft MW, Madsen AH, Carvalho B, de Wit M, Carey J, Dracopoli NC, Maddala T, Fang KC, Hartman AR, Forde PM , Anagnostou V, Brahmer JR, Fijneman RJA, Nielsen HJ, Meijer GA, Andersen CL, Mellemgaard A, Bojesen SE, Scharpf RB, Velculescu VE. Detection and Characterization of Lung Cancer Using Cell-Free DNA Fragmentomes. Nat Commun. 2021.

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