Discovering Rational Discovery Strategies for Degrading Cancer-Driving Transcription Factors

Dr. DoCong is pioneering advanced Targeted Protein Degradation (TPD) methods using covalent chemoproteomic strategies. The goal is to discover effective chemical design principles for creating molecular glue degraders, monovalent degraders, and destabilizing degraders against notoriously challenging oncogenic transcription factors and regulators implicated in human cancers.