Dr. Uckelmann is studying how nucleophosmin mutations in acute myeloid leukemia lead to epigenetic changes that shift pre-leukemic and leukemic cells to a dependency on the histone methyl transferase, MLL1, and its adaptor protein, Menin and how this dependency can be exploited in treatment strategies.
Uckelmann HJ, Haarer EL, Takeda R, Wong EM, Hatton C, Marinaccio C, Perner F, Rajput M, Antonissen NJC, Wen Y, Yang L, Brunetti L, Chen CW, Armstrong SA. Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia. Cancer Discov. 2023.