Dr. Melo-Cardenas has been awarded a grant focused on studying alterations in large cells in the bone marrow called megakaryocytes, and exploring how changes in the bone marrow microenvironment contribute to disease progression in primary myelofibrosis, a blood cancer characterized by a buildup of fibrous tissue that impairs the bone marrow’s ability to produce normal blood cells.
Content courtesy of Leukemia & Lymphoma Society
Melo-Cardenas J, Bezavada L, Crawford JC, Gurbuxani S, Cotton A, Kang G, Gossett JM, Marinaccio C, Weinberg RS, Hoffman R, Migliaccio AR, Zheng Y, Derecka M, Rinaldi CR, Crispino JD. IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms. Blood. 2022.