Gregory L. Beatty, MD, PhD, University of Pennsylvania, will study how the liver affects cancer immunotherapy efficacy. The goals of his project are to define determinants of the liver response to human cancer and to interrogate mechanisms by which the liver coordinates immune dysfunction. In doing so, Beatty aims to identify novel therapeutic targets and new treatments for patients with cancer.
“I am so thrilled to receive this AACR-The Mark Foundation for Cancer Research “Science of the Patient” Grant, which will allow my research team and me to conduct studies on the connection between the liver, cancer, and immunity, and follow our vision of broadening the efficacy of immunotherapy,” said Beatty.
Content courtesy of AACR
PUBLISHED RESEARCH
Lee J, Beatty GL. Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer. Cancers (Basel). 2021.
Li Y, Chang RB, Stone ML, Delman D, Markowitz K, Xue Y, Coho H, Herrera VM, Li JH, Zhang L, Choi-Bose S, Giannone M, Shin SM, Coyne EM, Hernandez A, Gross NE, Charmsaz S, Ho WJ, Lee JW, Beatty GL. Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer. Cell Rep Med. 2024.