In vivo Forward Genetic Screens to Identify Immunotherapy Resistance Mechanisms and Synergistic Treatment Combinations for Cancer


2021 Emerging Leader Award

Hao Zhu, MD, Children’s Medical Center Research Institute at UT Southwestern

Dr. Zhu’s lab develops mouse models of hepatobiliary cancers. He has pioneered in vivo pooled CRISPR screening approaches to identify novel biological pathways, with the goal of dissecting the relationship between cancer and regeneration. With this project, he is applying these technologies to the problem of resistance to immune checkpoint inhibitors. This work focuses on identifying genes that promote or inhibit immune clearance of tumors in the presence of immune checkpoint inhibitors. By performing iterative screens with understudied candidate pools and subsequently validating the most promising hits, Dr. Zhu hopes to identify therapeutic approaches to increase the effectiveness of immune checkpoint inhibitors across different types of cancer.

Dr. Zhu earned his bachelor’s degree in biology from Duke University, followed by an MD from Harvard Medical School and MIT. He underwent training in internal medicine at University of California, San Francisco and medical oncology at the Dana-Farber Cancer Institute. Dr. Zhu’s lab is focused on understanding the connections between tissue injury, regeneration, and cancer.

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