Defining the Transcriptomic and Epigenetic Reprogramming of Human Tumor-Infiltrating CD8 T Cells After PD-1 Blockade

Cancer Research Institute - Mark Foundation Postdoctoral Fellow (2019-Present)

Josephine Giles, PhD, University of Pennsylvania School of Medicine

Dr. Giles is determining how blocking the signals that inhibit T-cell function causes reprogramming at the epigenetic level resulting in more effective cytotoxic function.

published research

Mathew D, Giles JR, Baxter AE, Oldridge DA, Greenplate AR, Wu JE, Alanio C, Kuri-Cervantes L, Pampena MB, D’Andrea K, Manne S, Chen Z, Huang YJ, Reilly JP, Weisman AR, Ittner CAG, Kuthuru O, Dougherty J, Nzingha K, Han N, Kim J, Pattekar A, Goodwin EC, Anderson EM, Weirick ME, Gouma S, Arevalo CP, Bolton MJ, Chen F, Lacey SF, Ramage H, Cherry S, Hensley SE, Apostolidis SA, Huang AC, Vella LA; UPenn COVID Processing Unit, Betts MR, Meyer NJ, Wherry EJ. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science. 2020.