Dr. von Diezmann studies how cells control the pathways used to repair DNA. Errors in DNA repair contribute to the development of many cancers, such as breast, ovarian, and pancreatic cancers. Dr. von Diezmann will explore the basic principles governing the DNA damage response by examining how a specific subtype of homologous repair enzymes functions in reproductive cells of the model organism C. elegans. Her project will provide mechanistic insight into how changes in the liquid-like organization of proteins at sites of DNA damage regulate repair, supporting the development of novel chemotherapies that modulate the DNA damage response.
Content courtesy of Damon Runyon Cancer Research Foundation
von Diezmann L, Rog O. Single-Molecule Tracking of Chromatin-Associated Proteins in the C. elegans Gonad. J Phys Chem B. 2021.
Almanzar DE, Gordon SG, Bristow C, Hamrick A, von Diezmann L, Liu H, Rog O. Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex. Life Sci Alliance. 2023.