Liver PAH Defect Provokes Immune Resistance

In Partnership with The American Association for Cancer Research (2020-Present)

Liuqing Yang, PhD, The University of Texas MD Anderson Cancer Center

Liuqing Yang, PhD

Liuqing Yang, PhD, The University of Texas M.D. Anderson Cancer Center, will focus on the molecular mechanism of immunotherapy-associated liver impairment and its effects on a patient’s metabolic microenvironment and acquired resistance to immunotherapy treatments. Findings may influence current clinical management and pave the way for treatments targeting liver function to overcome acquired resistance.

“We are immensely thankful for the support provided by the AACR and The Mark Foundation,” said Yang. “Our studies are aimed at improving clinical outcomes for a wide range of patients undergoing immunotherapeutic cancer treatments, and the discoveries made with the support of this grant will be critical to future considerations for immunotherapy.”

Content courtesy of AACR.

published research

Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, Johnson DB, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ, Lin C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Sci Transl Med. 2022.