Targeting Insulin to Improve Endometrial Cancer

In Partnership with The American Association for Cancer Research (2020-Present)

Marcus D. Goncalves, MD, PhD, Weill Cornell Medicine

Marcus Goncalves, MD, PhD


Marcus D. Goncalves, MD, PhD, Weill Cornell Medicine, will use mouse models and data from human clinical trials to test if a very low carbohydrate diet reduces tumor insulin signaling, increases markers of cell death, and enhances the efficacy of PI3K inhibitors in endometrial cancer.

“Host factors are often overlooked in clinical trials and basic research,” said Goncalves. “This unique grant provides critical support for us to highlight the role of diet and insulin in endometrial cancer progression.”

Content courtesy of AACR.