Marcus D. Goncalves, MD, PhD, Weill Cornell Medicine, will use mouse models and data from human clinical trials to test if a very low carbohydrate diet reduces tumor insulin signaling, increases markers of cell death, and enhances the efficacy of PI3K inhibitors in endometrial cancer.
“Host factors are often overlooked in clinical trials and basic research,” said Goncalves. “This unique grant provides critical support for us to highlight the role of diet and insulin in endometrial cancer progression.”
Content courtesy of AACR.
PUBLISHED RESEARCH
Blow T, Hyde PN, Falcone JN, Neinstein A, Vasan N, Chitkara R, Hurd MA, Sardesai S, Lustberg MB, Flory JH, Volek JS, Goncalves MD. Treating Alpelisib-Induced Hyperglycemia with Very Low Carbohydrate Diets and Sodium-Glucose Co-Transporter 2 Inhibitors: A Case Series. Integr Cancer Ther. 2021.
Taylor SR, Falcone JN, Cantley LC, Goncalves MD. Developing dietary interventions as therapy for cancer. Nat Rev Cancer. 2022.
Langer HT, Ramsamooj S, Liang RJ, Grover R, Hwang SK, Goncalves MD. Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer. Front Oncol. 2022.