Dr. Hai is deconstructing the process by which certain fungi produce natural products that could be useful as cancer drugs.
Hai Y, Tang Y. Biosynthesis of Long-Chain N-Acyl Amide by a Truncated Polyketide Synthase-Nonribosomal Peptide Synthetase Hybrid Megasynthase in Fungi. J Am Chem Soc. 2018.
Hai Y, Huang AM, Tang Y. Structure-guided function discovery of an NRPS-like glycine betaine reductase for choline biosynthesis in fungi. Proc Natl Acad Sci U S A. 2019.
Cai Y, Hai Y, Ohashi M, Jamieson CS, Garcia-Borras M, Houk KN, Zhou J, Tang Y. Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat Chem. 2019.
Hai Y, Jenner M, Tang Y. Complete Stereoinversion of l-Tryptophan by a Fungal Single-Module Nonribosomal Peptide Synthetase. J Am Chem Soc. 2019.
Hai Y, Huang A, Tang Y. Biosynthesis of Amino Acid Derived α-Pyrones by an NRPS-NRPKS Hybrid Megasynthetase in Fungi. J Nat Prod. 2020.
Hai Y, Jenner M, Tang Y. Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetase. Chem Sci. 2020.
Hai Y, Chen M, Huang A, Tang Y. Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids. J Am Chem Soc. 2020.
Jenner M, Hai Y, Nguyen HH, Passmore M, Skyrud W, Kim J, Garg NK, Zhang W, Ogorzalek Loo RR, Tang Y. Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis. Nat Commun. 2023.