Grantees publish 17 papers in high-impact journals
Mark Foundation grantees demonstrated the breadth and depth of their expertise in a series of compelling publications during the fourth quarter of 2024. From fundamental discoveries to translational breakthroughs, their work, supported by our programs as well as collaborative grants delivered in partnership with peer foundations, underscores the power of novel, multidisciplinary approaches to cancer research. Explore a selection of their findings below.
Engineered extrachromosomal oncogene amplifications promote tumorigenesis
Published in Nature by ASPIRE awardee Andrea Ventura, MD, PhD
Targeting peptide antigens using a multiallelic MHC I-binding system
Published in Nature Biotechnology by Andy Minn, MD, PhD, principal investigator of The Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution
Published in Nature Genetics by Emerging Leader Award winner Dan Landau, MD, PhD
Microbial transformation of dietary xenobiotics shapes gut microbiome composition
Published in Cell by Damon Runyon-Mark Foundation Postdoctoral Fellow Elizabeth Culp, PhD
Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR-T cell therapy
Published in Blood by Endeavor awardee Eran Elinav, MD, PhD
Diet and Immune Effects Trial (DIET) – a randomized, double-blinded dietary intervention study in patients with melanoma receiving immunotherapy
Published in BMC Cancer by ASPIRE awardee Jennifer McQuade, MD, MS
Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays
Published in eLife by Damon Runyon-Mark Foundation Postdoctoral Fellow by Jonathan Van Vranken, PhD
Transgelin 2 guards T cell lipid metabolism and antitumour function
Published in Nature by ASPIRE awardee Juan Cubillos-Ruiz, PhD
Deep profiling of gene expression across 18 human cancers
Published in Nature Biomedical Engineering by Emerging Leader Award winner Kamila Naxerova, PhD
Midkine as a driver of age-related changes and increase in mammary tumorigenesis
Published in Cancer Cell by The Mark Foundation for Cancer Research and the Samuel Waxman Cancer Research Foundation Aging and Cancer Initiative grantee Kornelia Polyak, MD, PhD
Diffusion within the synaptonemal complex can account for signal transduction along meiotic chromosomes
Published in Molecular Biology of the Cell by Damon Runyon-Mark Foundation Postdoctoral Fellow Lexy von Diezmann, PhD
Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma
Published in Nature Communications by Blood Cancer Discoveries Grant Program awardee Margaret Shipp, MD
CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual targeting antibody overcome antigen heterogeneity in AML
Published in Blood by Damon Runyon-Mark Foundation Physician-Scientist Mark Leick, MD
The T cell receptor sequence influences the likelihood of T cell memory formation
Published in Cell Reports by Cancer Grand Challenges MATCHMAKERS team lead Michael Birnbaum, PhD
P-stalk ribosomes act as master regulators of cytokine-mediated processes
Published in Cell by ASPIRE awardee Pia Kvistborg, PhD
An antibiotic that mediates immune destruction of senescent cancer cells
Published in the Proceedings of the National Academy of Sciences by ASPIRE awardee René Bernards, PhD
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
Published in Nature by ASPIRE awardee Tuomas Tammela, MD, PhD