Our Portfolio


Featured Projects

Molecular Mechanisms of Tumor Progression and Plasticity in Bladder Cancer

Endeavor Award (2020-Present)

Cory Abate-Shen, PhD, and Michael Shen, PhD, Columbia University - Principal Investigators

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Understand and Eliminate Metastatic Cancers

Endeavor Award (2020-Present)

Andrei Goga, MD, PhD; Eric Collisson, MD; Jay Debnath, MD, PhD; Sarah Knox, PhD; Jeroen Roose, PhD; and Valerie Weaver, PhD, University of California, San Francisco - Principal Investigators

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Host Response to Cancer

Endeavor Award (2020-Present)

Tobias Janowitz, MD, PhD and Semir Beyaz, PhD, Cold Spring Harbor Laboratory - Principal Investigators

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Induced Proximity for Destabilization of Core Regulatory Factors in Alveolar Rhabdomyosarcoma

ASPIRE Award (2020-Present)

Benjamin Stanton, PhD (Principal), Nationwide Children's Hospital and Jun Qi, PhD, Dana-Farber Cancer Institute

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Evoking Immune Response Using Phosphorylation-Inducing Chimeric Small Molecules

ASPIRE Award (2020-Present)

Amit Choudhary, PhD, Harvard Medical School

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Evolutionary Distant DCC Populations Cooperate to Shape Lung Immune Niches for Dormancy and Reactivation

ASPIRE Award (2020-Present)

Julio Aguirre-Ghiso, PhD (Principal), Maria Soledad Sosa, PhD, and Brian Brown, PhD, Icahn School of Medicine at Mount Sinai

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New Molecular Glues to Target the RAS Pathway in Cancer

ASPIRE Award (2020-Present)

Arvin Dar, PhD, Icahn School of Medicine at Mount Sinai

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Development of a Brachyury Degrader

Drug Discovery Partnership (2020-Present)

Craig Crews, PhD, Yale University

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Optimizing MAPK Inhibitor Therapy for Pancreatic Cancer

ASPIRE Award (2020-Present)

Kevin Haigis, PhD (Principal) and Andrew Aguirre, MD, PhD, Dana-Farber Cancer Institute; Forest White, PhD, Massachusetts Institute of Technology

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Expanding Bifunctional Molecules to Restore Function After SWI/SNF Loss

ASPIRE Award (2020-Present)

Courtney Hodges, PhD (Principal), Baylor College of Medicine and Nate Hathaway, PhD, University of North Carolina

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Chromosomal Rearrangements and Their Associated Neo-Antigens as Predictors of Response and Survival to PD-1 Inhibition in Mesothelioma

ASPIRE Award (2020-Present)

Aaron Mansfield, MD, Mayo Clinic

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Disabling ER Stress Sensors to Unlock Adaptive Immunity Against Cancer

ASPIRE AWARD (2018-2019; 2020-PRESENT)

Juan Cubillos-Ruiz, PhD, Weill Cornell Medicine

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Overcoming BRAF/MEK Inhibition Resistance in Anaplastic Thyroid Carcinoma

ASPIRE Award (2020-Present)

Jennifer Wang, MD (Principal); Mark Zafereo, MD; and Wenyi Wang, PhD, MD Anderson Cancer Center

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