April 29, 2025

Research Spotlight: Mark Foundation Grantees Advance Cancer Research with Q1 2025 Publications

Grantees publish 13 papers in high-impact journals

In the first quarter of 2025, Mark Foundation-supported researchers continued to push the boundaries of cancer science, publishing significant findings across leading scientific journals. From new insights into intricate molecular mechanisms to innovative therapeutic strategies, their work highlights the impactful results generated through our diverse funding programs and collaborative partnerships. Discover some highlights from Q1 2025 below.  

FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy
Published in Nature Cancer by Andy Minn, MD, PhD, principal investigator of The Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation 

Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency
Published in Nature Communications by ASPIRE awardee Benjamin Greenbaum, PhD 

Genesis and regulation of C-terminal cyclic imides from protein damage
Published in Proceedings of the National Academy of Sciences of the United States of America by ASPIRE awardee Christina Woo, PhD 

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy
Published in Nature Communications by Mark Foundation-Chordoma Foundation grant awardee David Drewry, PhD 

Distinct myeloid-derived suppressor cell populations in human glioblastoma
Published in
Science by Drew Pardoll, MD, PhD, principal investigator of The Mark Foundation Center for Advanced Genomics and Imaging 

Three-dimensional regulatory hubs support oncogenic programs in glioblastoma
Published in
Molecular Cell by Emerging Leader Award winner Eftychia Apostolou, PhD 

The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis
Published in iScience by ASPIRE awardee Johanna Joyce, PhD 

Quantifying cell divisions along evolutionary lineages in cancer
Published in Nature Genetics by Emerging Leader Award winner Kamila Naxerova, PhD 

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
Published in Immunity by Momentum Fellow Leire Bejarano Bosque, PhD 

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Published in Science by Emerging Leader Award winner Nikhil Joshi, PhD 

CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally
Published in Cell Systems by Emerging Leader Award winner Sabrina Spencer, PhD 

Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
Published in
Science Immunology by Momentum Fellow Shin Ngiow, PhD 

Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy
Published in Nature Cancer by Mark Foundation-Leukemia & Lymphoma Society Fellow Sylvain Simon, PhD 

 

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