Grantees publish 13 papers in high-impact journals
In the first quarter of 2025, Mark Foundation-supported researchers continued to push the boundaries of cancer science, publishing significant findings across leading scientific journals. From new insights into intricate molecular mechanisms to innovative therapeutic strategies, their work highlights the impactful results generated through our diverse funding programs and collaborative partnerships. Discover some highlights from Q1 2025 below.
FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy
Published in Nature Cancer by Andy Minn, MD, PhD, principal investigator of The Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation
Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency
Published in Nature Communications by ASPIRE awardee Benjamin Greenbaum, PhD
Genesis and regulation of C-terminal cyclic imides from protein damage
Published in Proceedings of the National Academy of Sciences of the United States of America by ASPIRE awardee Christina Woo, PhD
Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy
Published in Nature Communications by Mark Foundation-Chordoma Foundation grant awardee David Drewry, PhD
Distinct myeloid-derived suppressor cell populations in human glioblastoma
Published in Science by Drew Pardoll, MD, PhD, principal investigator of The Mark Foundation Center for Advanced Genomics and Imaging
Three-dimensional regulatory hubs support oncogenic programs in glioblastoma
Published in Molecular Cell by Emerging Leader Award winner Eftychia Apostolou, PhD
The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis
Published in iScience by ASPIRE awardee Johanna Joyce, PhD
Quantifying cell divisions along evolutionary lineages in cancer
Published in Nature Genetics by Emerging Leader Award winner Kamila Naxerova, PhD
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
Published in Immunity by Momentum Fellow Leire Bejarano Bosque, PhD
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Published in Science by Emerging Leader Award winner Nikhil Joshi, PhD
CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally
Published in Cell Systems by Emerging Leader Award winner Sabrina Spencer, PhD
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
Published in Science Immunology by Momentum Fellow Shin Ngiow, PhD
Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy
Published in Nature Cancer by Mark Foundation-Leukemia & Lymphoma Society Fellow Sylvain Simon, PhD