12 high-impact papers reveal foundational and translational findings
From offering insights into geographic and age variations in colorectal cancer mutations to developing covalent degraders for prostate cancer cells, Mark Foundation grantees continued to drive the field forward with impactful publications in the second quarter of 2025. These developments highlight the real impact of both our grant programs and our partnerships with other research organizations. Discover highlights from Q2 2025 below.
Geographic and age variations in mutational processes in colorectal cancer
Published in Nature by the International Agency for Research on Cancer-Mark Foundation Postdoctoral Fellow Wellington Oliveira dos Santos, PhD
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling
Published in Nature Methods by Emerging Leader Award winner Dan Landau, MD, PhD
Covalent destabilizing degrader of AR and AR-V7 in androgen-independent prostate cancer cells
Published in Journal of the American Chemical Society by ASPIRE awardee Daniel Nomura, PhD
Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia
Published in Journal of Clinical Investigation by Mark Foundation-Leukemia & Lymphoma Society-Paul G. Allen Frontiers Group grantee Daniel Starczynowski, PhD
Probing condensate microenvironments with a micropeptide killswitch
Published in Nature by ASPIRE Awardee Denes Hnisz, PhD
FUT8 is a critical driver of prostate tumour growth and can be targeted using fucosylation inhibitors
Published in Cancer Medicine by Mark Foundation-Prostate Cancer Research grantee Jennifer Munkley, PhD
Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer
Published in Science Immunology by Emerging Leader Award winner Lydia Lynch, PhD
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics
Published in Nature by Emerging Leader Award winner Mario Suvà, MD, PhD
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias
Published in Cell by Mark Foundation-Leukemia & Lymphoma Society-Paul G. Allen Frontiers Group grantee Robert Bradley, PhD
CD40L stimulates tumor-infiltrating B-cells and improves ex vivo TIL expansion
Published in Journal for ImmunoTherapy of Cancer by ASPIRE Awardee Shari Pilon-Thomas, PhD
A neuroimmune circuit mediates cancer cachexia-associated apathy
Published in Science by Endeavor Award team member Tobias Janowitz, MD, PhD
Tissue mechanics in tumor heterogeneity and aggression
Published in Trends in Cancer by Momentum Fellow Anna-Marie Finger, PhD