The Mark Foundation is proud to support groundbreaking cancer research leading to several recent high-profile publications. These studies, ranging from the bench to the bedside, are funded by Mark Foundation grant programs including ASPIRE Award, Emerging Leader Award, Endeavor Award, and Momentum Fellowship, as well as through partnerships with other high-impact cancer research organizations. Scroll down to learn more.
- In Cancer Cell, Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade
- And Nature Genetics, Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer
- From the EXTOL Project Team (in partnership with Stand Up To Cancer)
- In Nature, Lung adenocarcinoma promotion by air pollutants
- From ASPIRE Awardee Charles Swanton
- In Cell Stem Cell, Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis.
- From Blood Cancer Discoveries Grant Awardee Robert Signer (in partnership with The Leukemia & Lymphoma Society and The Paul G. Allen Frontiers Group)
- In Molecular Cell, Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
- And Nature Genetics, Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.
- From Emerging Leader Awardee Cigall Kadoch
- In Nature, MEN1 mutations mediate clinical resistance to menin inhibition
- From Emerging Leader Awardee Eric Fischer, Momentum Fellows Florian Perner, Christian Marinaccio, and Jevon Cutler, and Scientific Advisory Committee members Scott Armstrong and Ross Levine
- In Nature Medicine, A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy.
- From Endeavor Awardees Eran Elinav, Cristoph Stein-Thoeringer, Michael Jain, Marco Davila, and Robert Jenq
- In Science, Structures of BIRC6-client complexes provide a mechanism of Smac-mediated release of caspases.
- From Emerging Leader Awardee Eric Fischer
- In Nature Communications, Accelerating inhibitor discovery for deubiquitinating enzymes.
- From ASPIRE Awardees Sara Buhrlage and Jarrod Marto
- In Nature, Slow TCA flux and ATP production in primary solid tumours but not metastases.
- From Damon Runyon – Mark Foundation Postdoctoral Fellow Caroline Bartman