Grantees publish 18 papers in high-impact journals
The year is off to a strong start for Mark Foundation investigators! In the first quarter, their Foundation-funded research has led to dozens of peer-reviewed papers spanning the full spectrum of cancer research—from fundamental biological mechanisms to new therapeutic strategies. Read a selection of their work below:
Aging-associated differences in mammary tumor–initiating populations
Published in Proceedings of the National Academy of Sciences by Aging and Cancer grantee Sandra McAllister, PhD
Tumor-derived aminopeptidase N promotes early stages of brain metastasis
Published in Cell Reports by Momentum Fellow Leire Bejarano Bosque, PhD
Systematic annotation of orphan RNAs reveals blood-accessible markers
Published in Cell Reports Medicine by ASPIRE awardee Hani Goodarzi, PhD
Epstein-Barr virus orchestrates spatial reorganization and immune evasion
Published in Cell Reports Medicine by Margaret Shipp, MD, recipient of a joint award from The Mark Foundation for Cancer Research, Leukemia & Lymphoma Society, and The Paul G. Allen Frontiers Group
NeoPrecis: enhancing immunotherapy response prediction through genomics
Published in Nature Communications by Emerging Leader Award winner Hannah Carter, PhD
PURE-seq integrates FACS and PIP-seq for single-cell genomics
Published in Nature Communications by Momentum Fellow Inés Fernández Maestre, PhD
CRISPR-based functional genomics for dissecting therapeutic dependencies
Published in Molecular Cell by Andy Minn, MD, PhD, director of the Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation at the University of Pennsylvania
BET inhibition blunts antibody production and macrophage mediation
Published in Blood by Momentum Fellow Elizabeth Garfinkle, PhD
The proteostasis network is a therapeutic target in acute myeloid leukemia
Published in Blood by Robert Signer, PhD, recipient of a joint award from The Mark Foundation for Cancer Research, Leukemia & Lymphoma Society, and The Paul G. Allen Frontiers Group
M-PACT leverages cell-free DNA methylomes to achieve robust classification
Published in Nature Cancer by Emerging Leader Award winner Paul Northcott, PhD
Modeling lipid homeostasis using stable isotope tracing and flux analysis
Published in Cell Metabolism by Endeavor awardee Reuben Shaw, PhD
Sensitive detection of cancer antigens enabled by user-defined peptides
Published in Nature Biotechnology by Endeavor awardee Catherine Wu, MD
Somatic genomics as a discovery engine for biomedicine
Published in Cell by Emerging Leader Award winner Hao Zhu, MD
A convergent uPAR-positive tumor ecosystem creates broad vulnerability
Published in Cell by Endeavor awardee Scott Lowe, PhD
A tumor-associated photoreceptor signature unifies distinct central nervous system tumors
Published in Cancer Cell by Emerging Leader Award winner Paul Northcott, PhD
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor decoy
Published in Science by Emerging Leader Award winner Cigall Kadoch, PhD
Rewiring STAT signaling from the cell surface with Trikine immunotherapies
Published in Science by Endeavor awardee Julien Sage, PhD
Overcoming T cell tolerance to tumor self-antigens through catch-bond design
Published in Science by Cancer Grand Challenges MATCHMAKERS team lead Michael Birnbaum, PhD