Grantees publish 15 papers in top journals
In the second quarter of 2024, a wave of new publications advancing cancer research showcased the dedication and innovation of investigators funded by the Mark Foundation. These impactful studies, spanning the research spectrum from bench to bedside, highlight the progress being made toward new therapies and improved patient outcomes and showcase the power of collaboration and cutting-edge science supported by the Mark Foundation’s ASPIRE, Emerging Leader, Endeavor, and Momentum programs. Explore their findings below.
Targetable leukaemia dependency on noncanonical PI3Kγ signalling
Published in Nature by Emerging Leader Award winner Andrew Lane, MD, PhD
Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients
Published in Science by Andy Minn, MD, PhD, Principal Investigator of The Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation
Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment
Published in Nature Medicine by ASPIRE awardee and Emerging Leader Award winner Dan Landau, MD, PhD
Why do patients with cancer die?
Published in Nature Reviews Cancer by ASPIRE awardee Erik Sahai, PhD; ASPIRE II awardee Charles Swanton, FRCP, BSc, PhD; and Endeavor awardee Tobias Janowitz, MD, PhD
Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins
Published in Nature Immunology by Science of the Patient grantee Gregory Beatty, MD, PhD (in partnership with The American Association For Cancer Research)
Metabolic inflexibility promotes mitochondrial health during liver regeneration
Published in Science by Emerging Leader Award winner Hao Zhu, MD
Obesity induces PD-1 on macrophages to suppress anti-tumour immunity
Published in Nature by Published in Nature by Endeavor awardees Jeffrey Rathmell, PhD; Alyssa Hasty, PhD; and Kathryn Wellen, PhD
Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone
Published in EBioMedicine by Prostate Cancer Research grantee Jennifer Munkley, PhD (in partnership with Prostate Cancer Research)
Preclinical efficacy of potent and selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias
Published in Blood by Momentum Fellow Jevon Cutler, PhD
The tidyomics ecosystem: enhancing omic data analyses
Published in Nature Methods by ASPIRE II awardee Kara Davis, DO
Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
Published in Nature by Emerging Leader Award winner Kıvanç Birsoy, PhD
A Hitchhiker’s guide to high-dimensional tissue imaging with multiplexed ion beam imaging
Published in Methods in Cell Biology by Blood Cancer Discoveries awardee Margaret Shipp, MD (in partnership with the Leukemia and Lymphoma Society and Paul G. Allen Frontiers Group)
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX
Published in Nature Communications by Momentum Fellow Mihaela Angelova, PhD
Body mass index and adiposity influence responses to immune checkpoint inhibition in endometrial cancer
Published in The Journal of Clinical Investigation by Emerging Leader Award winner Paul Cohen, MD, PhD
GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
Published in Molecular Cell by Blood Cancer Discoveries grantee Robert Bradley, PhD (in partnership with the Leukemia and Lymphoma Society and Paul G. Allen Frontiers Group)