Grantees publish 12 papers in top journals
In the third quarter of 2024, Mark Foundation grantees have continued to drive significant advances in our understanding and treatment of cancer. From uncovering potential new targets against lung cancer to exploring the causes and consequences of micronuclear collapse, these researchers are making remarkable progress toward improving patient outcomes. Delve into a selection of their latest impactful publications below, showcasing the breadth and depth of research powered by Mark Foundation funding.
Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity
Published in Cell by Life Sciences Research Foundation-Mark Foundation Postdoctoral Fellow Amy Strom, PhD
High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits Published in Nature Biotechnology by Life Sciences Research Foundation-Mark Foundation Postdoctoral Fellow by Ayano Kohlgruber, PhD
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Published in Cancer Cell by Cigall Kadoch, PhD
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer
Published in Nature Communications by David McConkey, PhD
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity
Published in Nature Immunology by Darrell Irvine, PhD
Joint AI-driven event prediction and longitudinal modeling in newly diagnosed and relapsed multiple myeloma
Published in npj Digital Medicine by David Sontag, PhD
Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer
Published in Nature by Kıvanç Birsoy, PhD
Epigenetic regulation of non-canonical menin targets modulates menin inhibitor response in acute myeloid leukemia
Published in Blood by Rui Lu, PhD
Micronuclear collapse from oxidative damage
Published in Science by Samuel Bakhoum, MD, PhD
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
Published in Science by Samuel Bakhoum, MD, PhD
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
Published in Cell by Shin Ngiow, PhD
IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β–mediated immune suppression and potentiate anti-tumor responses in glioblastoma
Published in Neuro-Oncology by Yvonne Chen, PhD